Study (reference) | Chemotherapy regimen | Subgroup | IT agent (target) | Control | EFS results (IT versus control) | ||
Number | pCR* (%) | Number | pCR* (%) | ||||
Pembrolizumab (PD-1) | Placebo | ||||||
KEYNOTE-522[1,2] | Weekly paclitaxel with carboplatin (weekly or every 3 weeks) for 12 weeks followed by doxorubicin or epirubicin and cyclophosphamide for 4 cycles | All | 784 | 65 | 390 | 51 | At median follow-up of 39 months, 3-year EFS 84 versus 77% (HR 0.63, 95% CI 0.48-0.82) |
PD-L1+ | 656 | 69 | 317 | 55 | |||
PD-L1– | 127 | 45 | 69 | 30 | |||
I-SPY2[3] | Weekly paclitaxel for 12 weeks followed by doxorubicin and cyclophosphamide for 4 cycles | All | 28 | 60 | 80 | 22 | Not reported |
Atezolizumab (PD-L1) | Placebo | ||||||
Impassion031[4] | Weekly nabpaclitaxel for 12 weeks followed by doxorubicin and cyclophosphamide for 4 cycles | All | 165 | 58 | 168 | 41 | At approximately 20 months' median follow-up, EFS not reached (HR 0.76, 95% CI 0.4-1.44) |
PD-L1+ | 77 | 69 | 75 | 49 | |||
PD-L1– | 88 | 48 | 93 | 34 | |||
Atezolizumab (PD-L1) | None | ||||||
NeoTRIPaPDL1[5] | Nabpaclitaxel and carboplatin days 1 and 8 every 21 days for 8 cycles | All | 138 | 44 | 142 | 41 | Not reported |
PD-L1+ | 79 | 52 | 77 | 48 | |||
PD-L1– | 59 | 32 | 65 | 32 | |||
Durvalumab (PD-L1) | Placebo | ||||||
GeparNUEVO[6,7] | Weekly nabpaclitaxel for 12 weeks followed epirubicin and cyclophosphamide for 4 cycles | All | 88 | 53 | 86 | 44 | At median follow-up of 42 months, 3-year iDFS 85 versus 77% (HR 0.54, 95% CI 0.27-1.09) |
PD-L1+ | 69 | 58 | 69 | 51 | |||
PD-L1– | 11 | 44 | 9 | 18 | |||
Window¶ | 59 | 61 | 58 | 41 |