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Worksheet for calculation of the breast cancer-specific GPA

Prognostic factor	GPA					Patient score
Prognostic factor	0	0.5	1.0	1.5	2.0	Patient score
KPS	≤60	70-80	90-100
Age, years	≥60	<60
Number of BM	≥2	1
ECM	Present	Absent
Subtype	Basal	Luminal A		HER2 or luminal B
						Sum = median survival by GPA: 0-1 = 6 months; 1.5-2.0 = 13 months; 2.5-3.0 = 24 months; 3.5-4.0 = 36 months

Breast cancer subtypes: basal = triple negative (ER/PR/HER2–); luminal A (ER/PR+, HER2–); luminal B (triple positive, ER/PR/HER2+); HER2 (HER2+, ER/PR–).

GPA: graded prognostic assessment; KPS: Karnofsky Performance Status; BM: brain metastases; ECM: extracranial metastases; HER2: human epidermal growth factor receptor 2.

From: Sperduto PW, Mesko S, Li J, et al. Survival in patients with brain metastases: Summary report on the updated diagnosis-specific graded prognostic assessment and definition of the eligibility quotient. J Clin Oncol 2020; 38:3773. DOI: 10.1200/JCO.20.01255. Copyright © 2020 American Society of Clinical Oncology. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.

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