Medication | Dose* | Administration | |
Alfuzosin (Uroxatral, Xatral) | Initial and maintenance | 10 mg | Once daily immediately following a meal at the same time each day |
Silodosin (Rapaflo) | Initial and maintenance | 8 mg | Once daily with a meal at the same time each day |
Tamsulosin (Flomax) | Initial and maintenance | 0.4 mg | Once daily approximately 30 minutes after a meal at the same time each day; 0.8 mg dose may be administered as 0.4 mg twice daily |
If inadequate response after 2 to 4 weeks | 0.8 mg | ||
Tamsulosin extended-release (Flomax CR) (NOTE: formulation available in some countries other than the United States) | Initial and maintenance | 0.4 mg | Once daily with a meal at the same time each day; maximum dose 0.4 mg once daily |
Conventional agents: Titration recommended to reduce orthostatic effects Dose is advanced as shown if patient remains symptomatic and is tolerating current dose | |||
Doxazosin immediate-release (Cardura) | Days 1 to 3 | 1 mg | Once daily at bedtime |
Days 4 to 14 | 2 mg | ||
Weeks 2 to 6 | 4 mg | ||
Week 7 and thereafter | 8 mg | ||
Doxazosin extended-release (Cardura XL) | Days 1 to 21 | 4 mg | Once daily with morning meal |
Week 4 and thereafter | 8 mg | ||
Terazosin (Hytrin) | Standard titration (appropriate for most patients) | ||
Days 1 to 3 | 1 mg | Once daily at bedtime | |
Days 4 to 14 | 2 mg | ||
Weeks 2 to 6 | 5 mg | ||
Week 7 and thereafter | 10 mg | ||
If inadequate response after 4 to 6 weeks of 10 mg/day | 20 mg | ||
Rapid titration (for selected patients) | |||
Days 1 to 3 | 1 mg | Once daily at bedtime | |
Days 4 to 14 | 2 mg | ||
Weeks 2 to 3 | 5 mg | ||
Week 4 and thereafter | 10 mg | ||
If inadequate response after 4 to 6 weeks of 10 mg/day | 20 mg |