Pharmacologic class | Medication | Initial dose | Titration interval | Maximum dose |
Phosphodiesterase-5 (PDE-5) inhibitor* | Tadalafil (Cialis) | 5 mg daily | None | 5 mg daily |
5-alpha-reductase inhibitors (5-ARIs)¶ | Finasteride (Proscar) | 5 mg daily | None | 5 mg daily |
Dutasteride (Avodart) | 0.5 mg daily | None | 0.5 mg daily |
Beta-3 adrenergic agonists | Mirabegron (Myrbetriq) | 25 mg daily | May increase dose as needed and tolerated after ≥4 weeks | 50 mg daily |
Vibegron (Gemtesa) | 75 mg daily | None | 75 mg daily |
Anticholinergic agentsΔ | Fesoterodine (Toviaz) | 4 mg daily | May increase dose as needed and tolerated after ≥2 weeks | 8 mg daily |
Tolterodine IR (Detrol) | 1 to 2 mg twice daily | None | 2 mg twice daily |
Tolterodine ER (Detrol LA) | 2 to 4 mg daily | 4 mg twice daily |
Oxybutynin IR (Ditropan◊) | 5 mg 2 to 3 times daily | May increase dose as needed and tolerated in 5 mg increments every 1 to ≥2 weeks | 5 mg 4 times daily |
Oxybutynin ER (Ditropan XL) | 5 to 10 mg daily | 30 mg daily |
Darifenacin (Enablex) | 7.5 mg daily | May increase dose as needed and tolerated after ≥2 weeks | 15 mg daily |
Solifenacin (Vesicare) | 5 mg daily | 10 mg daily |
Trospium IR (Sanctura◊) | 20 mg twice daily (once daily if >75 years old) | None | 20 mg twice daily |
Trospium ER (Sanctura XR◊) | 60 mg daily | 60 mg daily |