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Environmental safety measures for heated intraperitoneal chemotherapy[1-3]

Environmental safety measures for heated intraperitoneal chemotherapy[1-3]
Pre-HIPEC
Educate OR personnel regarding environmental concerns.
All OR personnel should don airborne, droplet and contact PPE prior to HIPEC:
  • N95 mask
  • Eye protection (goggles)
  • Impervious gown
  • Disposable impervious shoe covers
  • Gloves
Use impervious, disposable surgical drapes.
Place absorbent towels with impervious backing on the floor and around the base of the OR table for spills.
Use leak-proof biohazard disposal containers in the OR.
Ensure proper operating room ventilation and air conditioning.
HIPEC phase
Surgeons in contact with HIPEC solution should wear triple gloves, including elbow length gloves.
Change gloves immediately after overt contamination, every 30 minutes for personnel handling cytotoxic agents.
Wash exposed skin immediately with additive free soap.
For eye exposure, flush with water or saline for five minutes.
Place a smoke evacuator under plastic sheet covering the abdomen to run continuously during HIPEC.
Nonessential personnel should leave the OR.
Secure OR door when HIPEC in progress.
Placed signs outside the OR to indicate that HIPEC is in progress and entry is restricted.
Post-HIPEC
Personnel who clean the OR after HIPEC should use the same PPE described above.
Clean up spills immediately. Blot dry, and clean with water and neutral soap. Avoid use of bactericidal cleaning solutions, which may react with cytotoxic agents.
All trash should be disposed of in leak-proof bins.
Surgical instruments and equipment should be washed three times with water and pure soap.
Institute medical surveillance of OR personnel involved with HIPEC.
HIPEC: heated intraperitoneal chemotherapy; OR: operating room; PPE: personal protective equipment.
References:
  1. Bhatt A, Mittal S, Gopinath KS. Safety considerations for Health care Workers involved in Cytoreductive Surgery and Perioperative chemotherapy. Indian J Surg Oncol 2016; 7:249.
  2. Easty AC, Coakley N, Cheng R, et al. Safe handling of cytotoxics: guideline recommendations. Curr Oncol 2015; 22:e27.
  3. González-Bayón L, González-Moreno S, Ortega-Pérez G. Safety considerations for operating room personnel during hyperthermic intraoperative intraperitoneal chemotherapy perfusion. Eur J Surg Oncol 2006; 32:619.
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