Traditional approach for children >1 month and adolescents | Typically 15 mg/kg per dose IV every 6 to 8 hours[1]: - Use the every-6-hour interval for serious infections*
- Maximum daily dose: 4 g/day
| Either: - Continue initial dose (for most children, particularly if duration of vancomycin is expected to be <3 days)¶
- Based on trough-guided serum concentration monitoring for select children (eg, those with renal dysfunction, infective endocarditis, risk factors for altered vancomycin kinetics [eg, fluid overload, critical illness])
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