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Molecular subtypes of gastric adenocarcinoma

Molecular subtypes of gastric adenocarcinoma
Subtypes Frequency Genomic alterations Predominant histopathology Other features
GS ~20%

CDH1 alteration

RHOA alteration
Poorly cohesive

Younger patients

Worst prognosis
CIN ~50%

TP53 mutation

ERBB2 amplification

KRAS mutation
Intestinal

Male predominance

High rate of nodal metastases
MSI ~22%

CMIP

MLH1 sequencing

ARID1A mutation
Intestinal

Distal stomach

Low rate of nodal metastases
EBV-positive ~8%

CMIP

PIK3 mutation

ARID1A mutation

PDL1/L2 amplification
Medullary (some intestinal)

Proximal stomach

Low rate of nodal metastases
GS: genetically stable; CIN: chromosome instable; MSI: microsatellite instable; EBV: Epstein-Barr virus.
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