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Preventive medications for treatment of migraine[1]

Preventive medications for treatment of migraine[1]
Class FDA approved for indication Class of evidence
Beta blockers: Propranolol, timolol Yes A
Calcium channel blockers: Verapamil No B
Antidepressants: Amitriptyline, nortriptyline, venlafaxine No B
Antiseizure medications: Sodium valproate, topiramate Yes A
NSAIDs: Naproxen No B
Onabotulinum toxin Yes A
CGRP monoclonal antibodies: Fremenazumab, galcanazemab, erenumab Yes A
FDA: US Food and Drug Administration; A: high-quality evidence from more than 1 RCT, meta-analyses of high-quality RCTs, 1 or more RCTs corroborated by high-quality registry studies; B: moderate-quality evidence from 1 or more RCTs, meta-analyses of moderate-quality RCTs; NSAIDs: nonsteroidal anti-inflammatory drugs; CGRP: calcitonin gene-related peptide; RCT: randomized controlled trials.
Reference:
  1. Loder E, Burch R, Rizzoli P. The 2012 AHS/AAN guidelines for prevention of episodic migraine: a summary and comparison with other recent clinical practice guidelines. Headache 2012; 52:930.
From: Bernstein C, O'Neal M. Migraine and menopause - a narrative review. Menopause 2020. DOI: 10.1097/GME.0000000000001635. Copyright © 2020 The North American Menopause Society. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.
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