Drug | Oral dose | Comments |
Oxycodone | - ≤6 months of age: 0.025 to 0.05 mg/kg orally every 4 to 6 hours
- >6 months of age: 0.05 to 0.1 mg/kg orally every 4 to 6 hours, maximum 5 to 10 mg orally
| Available as a tablet or oral solution (1 mg/mL); concentrated solution (20 mg/mL) should not be used in opioid naïve children |
Hydromorphone | - 0.03 mg/kg orally every 4 to 6 hours
| Available as a tablet or oral solution (1 mg/mL) |
Morphine | - 0.3 mg/kg orally every 4 to 6 hours, maximum 15 mg
| Available as tablet or oral solution (2 mg/mL) |
Hydrocodone | | Not recommended due to availability only in combination with acetaminophen or ibuprofen |