Recommended post-exposure vaccination schedules for anthrax vaccine absorbed[1]
Recommended post-exposure vaccination schedules for anthrax vaccine absorbed[1]
Dose (mL)
Route of administration
Schedule
Standard regimen
0.5
Subcutaneous
3 doses post exposure:
0 weeks
2 weeks
4 weeks
Dose-sparing regimens*
0.5
Subcutaneous or intramuscular¶
2 doses post exposure:
0 weeks
2 to 4 weeks
0.25
3 doses post exposure:
0 weeks
2 weeks
4 weeks
These vaccine regimens are for individuals who did not receive pre-exposure vaccination. Refer to other UpToDate content for details on post-exposure prophylaxis in individuals who have already received anthrax vaccination.
* A dose-sparing regimen of anthrax vaccine adsorbed can be used if the supply is not sufficient to allow standard vaccination for all exposed individuals.
¶ Vaccine can be administered intramuscularly if subcutaneous administration poses significant challenges that might delay or preclude vaccination.
Reference:
Bower WA, Schiffer J, Atmar RL, et al. Use of Anthrax Vaccine in the United States: Recommendations of the Advisory Committee on Immunization Practices, 2019. MMWR Recomm Rep 2019; 68:1.
