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Diseases in which IgG4 serum levels may sometimes be elevated[1-3]

Diseases in which IgG4 serum levels may sometimes be elevated[1-3]
Disease*
Autoimmune diseases
ANCA-associated vasculitis
Rheumatoid arthritis
Systemic lupus erythematosus
Systemic sclerosis
Sjögren's syndrome
Spondyloarthritis
Gastrointestinal disorders
Acute pancreatitis
Autoimmune hepatitis
Chronic pancreatitis
Chronic hepatitis
Cirrhosis
Ulcerative colitis
Lymphoproliferative/granulomatous diseases and solid tumors
Castleman disease
Sarcoidosis
Cholangiocarcinoma
Colorectal cancer
Lung cancer
Pancreatic cancer
Urogenital cancer
Other diseases
Allergies
Asthma
IgG4: immunoglobulin G4; ANCA: antineutrophil cytoplasmic antibodies.
* Other diseases not recorded in this table have been also reported more rarely to have high IgG4 serum levels.
Adapted from: Brito-Zerón P, Bosch X, Ramos-Casals M, Stone JH. IgG4-related disease: Advances in the diagnosis and treatment. Best Pract Res Clin Rheumatol 2016; 30:261.
References:
  1. Yamamoto M, Tabeya T, Naishiro Y, et al. Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases. Mod Rheumatol 2012; 22:419.
  2. Su Y, Sun W, Wang C, et al. Detection of serum IgG4 levels in patients with IgG4-related disease and other disorders. PLoS One 2015; 10:e0124233.
  3. Yu KH, Chan TM, Tsai PH, et al. Diagnostic performance of serum IgG4 levels in patients with IgG4-related disease. Medicine (Baltimore) 2015; 94:e1707.
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