| Patient characteristics |
| Use of multiple medications (polypharmacy) |
| Multimorbidity |
| Renal impairment |
| Multiple prescribers |
| Transitions of care |
| Medication nonadherence |
| Limited life expectancy |
| Frailty |
| Dementia |
| Medications |
| Strongly anticholinergic medications (eg, first-generation antihistamines) |
| Benzodiazepines |
| Benzodiazepine receptor agonists |
| Long-acting sulfonylureas |
| Insulins in patients who could reach appropriate glycemic targets with less or safer glucose-lowering therapy |
| Chronic use of proton pump inhibitors without strong indication |
| Chronic use of NSAIDs without strong indication |
| Aspirin for primary prevention of cardiovascular disease in older patients |
