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Mechanism-based analgesic targets

Mechanism-based analgesic targets
Major analgesic target/activity Drug/class
Binding site
  • Mu-opioid receptor
 Opioids, tramadol
  • Sodium ionic channel
 Lidocaine, carbamazepine, lamotrigine
  • Calcium ionic channel
 Gabapentin, pregabalin
Neurotransmitter
  • Inhibition norepinephrine reuptake
 Tricyclic and SNRI antidepressants
  • Alpha2-adrenoreceptor agonist
 Tizanidine, clonidine
Enzyme inhibition
  • Cyclooxygenase types 1 ≥ 2
 Non-selective NSAIDS
  • Cyclooxygenase types 2 ≥ 1
 Selective NSAIDs
SNRI: serotonin-norepinephrine reuptake inhibitor; NSAID: nonsteroidal antiinflammatory drug.
Graphic 126429 Version 2.0