- Musculoskeletal: Spinal pain syndromes (eg, degenerative disc disease with or without spinal stenosis, post-laminectomy, and post-fusion surgeries); osteoarthritis; regional muscle pain disorders
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- Neurologic: Migraine and other recurring headache disorders, including tension-type headaches; peripheral and traumatic neuropathies; trigeminal neuropathies and neuralgia; multiple sclerosis
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- Gastrointestinal: Irritable bowel syndrome; Crohn disease; ulcerative colitis; pancreatitis
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- Urogynecological: Interstitial cystitis (bladder pain syndrome); vulvodynia; chronic endometriosis; chronic (male and female) pelvic pain
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- Metabolic: Diabetes (peripheral neuropathy); pernicious anemia
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- Infectious: Post-herpetic neuralgia; HIV-associated neuropathy; Lyme disease
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- Autoimmune disorders: Rheumatoid arthritis; systemic lupus erythematosus; spondyloarthropathies; Sjögren's syndrome; chronic inflammatory demyelinating polyneuropathy
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- Neoplastic: Cancer survivor pain syndromes
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