your limit has been reached. plz Donate us to allow your ip full access, Email: sshnevis@outlook.com

Pathogen inactivation methods

Method	Used for	Comments	Licensure
Solvent/detergent treatment	Plasma	Damages lipid membranes Destroys lipid-enveloped viruses (HIV, HCV, HBV, HTLV, EBV, CMV) Does not inactivate non-enveloped viruses (HAV, HEV, parvovirus B19) Used in "Octaplas" system	CE marked FDA approved
Amotosalen + UVA light	Cryoprecipitate; plasma; platelets	Crosslinks DNA, preventing replication Used in "INTERCEPT" systems	CE marked FDA approved
Riboflavin + UV light	Cryoprecipitate; plasma; platelets; whole blood	Oxidizes guanine nucleotides in DNA, preventing replication Used in "Mirasol" systems	CE marked
Methylene blue + visible light	Cryoprecipitate; plasma	Inactivates lipid-enveloped viruses May reduce concentrations of some clotting factors Used in "THERAFLEX" systems	CE marked
UV light alone	Platelets	Damages DNA, preventing replication Used in "THERAFLEX" systems	CE marked

These methods are used for plasma and cellular products (eg, platelets). Plasma derivatives (immune globulins, albumin, coagulation factors) undergo additional purification and fractionation steps, freezing and thawing, and/or lyophilization, which further inactivates pathogens. Refer to UpToDate and the product information for details of these products.

HCV: hepatitis C virus; HBV: hepatitis B virus; HTLV: human T-cell leukemia virus; EBV: Epstein-Barr virus; CMV: cytomegalovirus; HAV: hepatitis A virus; HEV: hepatitis E virus; CE: "Conformité Européenne," a mark of conformity to European standards for products sold in the European Union; FDA: US Food and Drug Administration; UV: ultraviolet.

Graphic 126099 Version 3.0