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Causes of secondary immune thrombocytopenia (ITP)

Causes of secondary immune thrombocytopenia (ITP)
Autoimmune syndromes
  • Antiphospholipid syndrome (APS)
  • Autoimmune lymphoproliferative syndrome (ALPS)
  • Evans syndrome
  • Inflammatory bowel disease
  • Rheumatoid arthritis
  • Systemic lupus erythematosus (SLE)
Immunodeficiency syndromes
  • Common variable immune deficiency (CVID)
  • HIV
  • Selective IgA deficiency
Infections
  • Cytomegalovirus (CMV)
  • Epstein-Barr virus (EBV)
  • Hepatitis C virus (HCV)
  • Helicobacter pylori
  • HIV
  • Varicella zoster virus (VZV)
  • Zika virus
Lymphoid malignancies
  • Chronic lymphocytic leukemia (CLL)
  • Lymphoma
Medications or vaccines
  • Alemtuzumab
  • Gold
  • Ipilimumab
  • Measles, mumps, and rubella (MMR) vaccination
  • Nivolumab
  • Pembrolizumab
Refer to UpToDate for information about the associations and appropriate testing.
ITP: immune thrombocytopenia; IgA: immunoglobulin A.
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