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Rates of dMMR or MSI-H in advanced/metastatic cancer across 2 different panels, expressed as a percentage

Rates of dMMR or MSI-H in advanced/metastatic cancer across 2 different panels, expressed as a percentage
Tumor type Fraction with mismatch repair abnormalities
Assessed by dMMR
(Le, 2017)[1]
Assessed by MSI-H
(Middha, 2017)[2]
Biliary 1 1.3
Bladder NR 3.1
Brain tumors <1
Breast <1
Cervical <1
Colorectal 3 8.3
Endometrial 6 16.2
Esophagus and esophagogastric junction 2.5*
Gastric adenocarcinoma 3 2.5*
Hepatocellular
Lung, non-small cell <1 <1
Lung, small cell 1 1.1
Neuroendocrine tumors 1 2.1
Ovarian <1
Pancreatic 1 <1
Prostate 1 1.7
Sarcoma, uterine <1 2
Skin, melanoma NR
Skin, Merkel cell NR NR
Skin, nonmelanoma NR 3.1
Small bowel 1 15.6
Soft tissue sarcoma, nonuterine <1
Thyroid carcinoma 2 <1
Unknown primary 1 2
dMMR: deficient mismatch repair; MSI-H: high levels of microsatellite instability; NR: not reported.
* Esophagogastric tumors, nongastrointestinal stromal tumors.
¶ Gastrointestinal.
References:
  1. ​Le DT, Durham JN, Smith KN, et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 2017; 357:409.
  2. Middha S, Zhang L, Nafa K, et al. Reliable pan-cancer microsatellite instability assessment by using targeted next-generation sequencing data. JCO Precis Oncol 2017.
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