| Technique | Cytogenetic analysis | FISH analysis | Microarray analysis | Next-generation sequencing |
| Resolution | 5 Mb | 100 to 300 kb | Variable to few kb | Single nucleotide |
| Lower limit of detection | 5% | ~1 to 5% | 15 to 20% | 2 to 20% |
| Detects copy-neutral LOH | No | No | Yes | Maybe |
| Cell division required | Yes | No | No | No |
| Detects balanced translocations/inversions | Yes | Yes | No | Yes/No |
| Detects unbalanced aberrations, eg, deletions, unbalanced translocations | Yes | Yes | Yes | Yes/No |
| Detects multiple clones | Yes | Yes/No | No | Yes/No |
| Screen for novel lesions | Yes | No | Yes | Yes |
