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Current proposed PET radiopharmaceuticals for PPGL imaging according to genetic background

Current proposed PET radiopharmaceuticals for PPGL imaging according to genetic background
  Location Other related tumor conditions First-choice radiopharmaceutical Second-choice radiopharmaceutical
SDHB Adrenal/extra-adrenal GISTs, RCCs, and pituitary adenomas 68Ga-DOTA-SSAs 18F-FDG
SDHD Adrenal/extra-adrenal GISTs, RCCs, and pituitary adenomas 68Ga-DOTA-SSAs 18F-FDG
SDHC Adrenal/extra-adrenal GISTs and RCCs 68Ga-DOTA-SSAs 18F-FDG
FH Adrenal/extra-adrenal Skin and uterine leiomyomas, RCCs, uterine leiomyosarcomas, and ovarian mucinous cystadenomas 18F-FDOPA 68Ga-DOTA-SSAs
VHL Adrenal/extra-adrenal RCCs, CNS hemangioblastomas, and pancreatic and testicular tumors 18F-FDOPA 68Ga-DOTA-SSAs
EPAS1/HIF2A Adrenal/extra-adrenal Somatostatinomas 18F-FDOPA 18F-FDG
MEN2 Adrenal MTC, parathyroid adenomas, or hyperplasia 18F-FDOPA 68Ga-DOTA-SSAs
NF1 Adrenal Neurofibromas, peripheral nerve sheath tumors, and gliomas 18F-FDOPA 68Ga-DOTA-SSAs
TMEM127 Adrenal RCCs 18F-FDOPA 68Ga-DOTA-SSAs
MAX Adrenal/extra-adrenal Renal oncocytomas 18F-FDOPA 68Ga-DOTA-SSAs
PET: positron emission tomography; PPGL: pheochromocytoma and paraganglioma; SDH: succinate dehydrogenase; GIST: gastrointestinal stromal tumor; RCC: renal cell carcinoma; 68Ga-DOTA: gallium Ga-68 DOTA; SSA: somatostatin analog; 18F-FDG: 18F-fludeoxyglucose; FH: fumarase hydratase; 18F-FDOPA: 18F-fluorodihydroxyphenylalanine; VHL: von Hippel-Lindau tumor suppressor; CNS: central nervous system; EPAS1: endothelial PAS domain-containing protein 1; HIF2A: hypoxia-inducible factor 2-alpha; MEN2: multiple endocrine neoplasia 2; MTC: medullary carcinoma of the thyroid; NF1: neurofibromatosis type 1 protein; TMEM127: transmembrane protein 127; MAX: MYC-associated factor X.
Reproduced from: Taïeb D, Pacak K. New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma. Trends Endocrinol Metab 2017; 28:807. Table used with the permission of Elsevier Inc. All rights reserved.
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