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Ventilatory acclimatization at altitude

The graphs above show the changes that occur in minute ventilation, end-tidal carbon dioxide, and oxygen saturation as climbers adapt to high altitude; in this case, 4300 meters at Pikes Peak.

SaO₂: arterial oxygen saturation; V_E: minute ventilation; BTPS: body temperature pressure saturated; PaCO₂: partial pressure of carbon dioxide; D: day.

Adapted with permission from: Huang SY, Alexander JK, Grover RF, et al. Hypocapnia and sustained hypoxia blunt ventilation on arrival at high altitude. J Appl Physiol Respir Environ Exerc Physiol 1984; 56:602. Copyright © 1984 The American Physiological Society. All rights reserved.

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