Primary PRCA |
Idiopathic (autoimmune) |
Initial presentation of MDS |
Transient erythroblastopenia of childhood (TEC)* |
Secondary PRCA |
Drugs |
Chlorpropamide |
Erythropoietin (EPO, recombinant) |
Immune checkpoint inhibitors (monoclonal antibodies targeting CTLA4, PD1, or PDL1) |
Mycophenolate mofetil |
Phenytoin |
Trimethoprim-sulfamethoxazole |
Zidovudine |
Infections |
B19 parvovirus (transient or chronic) |
Epstein-Barr virus |
HIV |
Viral hepatitis |
Immune disorders |
Autoimmune hemolytic anemia |
Systemic lupus erythematosus |
Rheumatoid arthritis |
ABO-incompatible hematopoietic stem cell transplant |
Neoplasms |
Lymphoid - CLL
- LGL leukemia
- Hodgkin lymphoma
- Non-Hodgkin lymphoma
- Multiple myeloma and other plasma cell disorders
|
Myeloid |
Other - Thymoma (approximately 5% of cases)
- Cancers with anemia treated with EPO
|
Pregnancy |