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Cumulative illness rating scale (CIRS) for patients with chronic lymphocytic leukemia (CLL)

Cumulative illness rating scale (CIRS) for patients with chronic lymphocytic leukemia (CLL)
Rating strategy of comorbidity
Organ system not compromised 0 = No problem
Illness/impairment with or without requirement of therapy, excellent prognosis, patient with normal activity 1 = Mild
Illness/impairment requiring therapy, good prognosis, compromised activity 2 = Moderate
Illness/impairment with urgent requirement of therapy, prognosis unclear, marked restriction in activity 3 = Severe
Life threatening illness/impairment, emergency case of therapy, adverse prognosis 4 = Extremely severe
Assess illness/impairment in each of the following systems on a scale from 1 to 4:
System Score
Heart  
Blood pressure  
Vascular  
Respiratory  
Eye/ear/nose/throat/larynx  
Upper gastrointestinal  
Lower gastrointestinal  
Liver  
Renal  
Genitourinary  
Musculoskeletal  
Endocrine/metabolic  
Neurological  
Psychiatric  
Total  
The CIRS rating scale is used to assess comorbidity in patients with CLL. CLL induced illness or organ damage are not included in this rating scale. If there are two or more illness/impairments of one organ system, the illness/impairment with the highest severity should be evaluated.
Adapted from:
  1. Goede V, Fischer K, Busch R, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med 2014; 370:1101.
  2. Linn BS, Linn MW, Gurel L. Cumulative illness rating scale. J Am Geriatr Soc 1968; 16:622.
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