Electron microscopy of ichthyosis vulgaris and control epidermis.
(A,B) Low-power electron microscopy (.3000) showing the lower stratum corneum (c), the area of the granular layer (*), and the upper spinous layer (s). Keratohyalin granules are present in the control (A) but not the affected (B) epidermis. The area of the upper spinous and the granular cells in the affected epidermis appear lighter because of reduced density of intermediate filaments. Biopsies were taken from buttock skin. Magnification bar = 1 micron.
(C,D) Higher-power electron microscopy (.15000) from the areas indicated by (*) in (A) and (B), demonstrating the lower stratum corneum (c) and keratohyalin granules (kh) in the control (C) but not the affected (D) epidermis. The areas of electron density in the affected skin (kf) are aggregated keratin intermediate filaments. Magnification bar = 0.5 micron.
From: Fleckman P, Brumbaugh S. Absence of the granular layer and keratohyalin define a morphologically distinct subset of individuals with ichthyosis vulgaris. Exp Dermatol 2002; 11(4):327-36.
https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1600-0625.2002.110406.x. Copyright © 2002 Blackwell Munksgaard 2002. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email:
permissions@wiley.com or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (
https://onlinelibrary.wiley.com/).
