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Clinical staging for medication-related osteonecrosis of the jaw (MRONJ) from the International Task Force on Osteonecrosis of the Jaw

Clinical staging for medication-related osteonecrosis of the jaw (MRONJ) from the International Task Force on Osteonecrosis of the Jaw
Stage Clinical description
1
  • Asymptomatic
  • Exposed bone on mandible or maxilla
  • No evidence of significant adjacent or regional soft tissue inflammation or secondary infection
2
  • Painful
  • Exposed bone on mandible or maxilla
  • Adjacent or regional soft tissue inflammation or secondary infection
3
  • Painful
  • Exposed bone on mandible or maxilla
  • Adjacent or regional soft tissue inflammation or secondary infection
  • Extraoral fistula or oral antral fistula or radiographic evidence of osteolysis extending to the inferior border of the mandible or the floor of the maxillary sinus
Reproduced with permission from: Aliya A. Khan. Originally published in: Khan AA, Morrison A, Hanley DA, et al. Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus. J Bone Miner Res 2015; 30:3. Copyright © 2015 Khan AA, Morrison A, Hanley DA, et al.
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