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The WHO 1st International Reference Reagents (IRR) for hCG and related variants[1,2]

The WHO 1st International Reference Reagents (IRR) for hCG and related variants[1,2]
WHO code Symbol Molecular structure and approximate weight (kDa)
99/688 hCG Intact alpha/beta heterodimer, bioactive hCG (36.7 kDa)
99/720 hCGa Free alpha-subunit, 92 AA, glycosylated (14.5 kDa)
99/863 hCGb Free beta-subunit, 145 AA, glycosylated (22.2 kDa)
99/708 hCGbcf Core fragment of hCG-beta, hCG-beta 6 to 40 linked to hCG-beta 55 to 92 (9.8 KDa)
99/642 hCGn Nicked hCG, missing linkages in the region hCG-beta 44 to 48 (36.7 KDa)
99/692 hCGbn Nicked hCG-beta, missing linkages in the region hCG-beta 44 to 48 (22.2 KDa)
WHO: World Health Organization; hCG: human chorionic gonadotropin; a: alpha; AA: amino acid; b: beta; cf: core fragment; n: nicked.
References:
  1. Birken S, Berger P, Bidart JM, et al. Preparation and characterization of new WHO reference reagents for human chorionic gonadotropin and metabolites. Clin Chem 2003; 49:144.
  2. Harvey RA, Mitchell HD, Stenman UH, et al. Differences in total human chorionic gonadotropin immunoassay analytical specificity and ability to measure human chorionic gonadotropin in gestational trophoblastic disease and germ cell tumors. J Reprod Med. 2010; 55:285.
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