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Calculator: Genetically inspired international prognostic scoring system (GIPSS) for primary myelofibrosis in adults


Calculator: Genetically inspired international prognostic scoring system (GIPSS) for primary myelofibrosis in adults

 
Karyotype classification:*

Very high risk (VHR) (2 points)

Unfavorable (1 point)

Favorable (0 points)
Driver mutations:

Absence of type 1-like CALR (1 point)
High molecular risk (HMR) mutations:**

ASXL1 mutation (1 point)

SRSF2 mutation (1 point)

U2AF1 Q157 mutation (1 point)

 
Important: Inputs must be complete to perform calculation.

 
Total criteria point count:
 

 

Interpretation

 
GIPSS score (points) Risk group 5-year overall survival Median overall survival (years)
0 Low risk 94% 26.4
1 Intermediate risk - 1 73% 10.3
2 Intermediate risk - 2 40% 4.6
3 to 6 High risk 14% 2.6

 
Notes
  • *Classification of karyotypes:
    • VHR: Single or multiple abnormalities of -7, i(17q), inv(3)/3q21, 12p-/12p11.2, 11q-/11q23, or other autosomal trisomies not including +8/+9 (eg, +21, +19).
    • Favorable: Normal karyotype or sole abnormalities of +9, 13q-, 20q-, chromosome 1 translocation/duplication, or sex chromosome abnormality including -Y.
    • Unfavorable: All other abnormalities.
  • **Classification of HMR mutations:
    • ASXL1 mutation = 1 point
    • SRSF2 mutation = 1 point
    • U2AF1 Q157 mutation = 1 point

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

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