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Uptodate Reference Title
Pathways involved in bradykinin (BK)-mediated angioedema
Pathways involved in bradykinin (BK)-mediated angioedema
Demonstration of the pathways involved in BK-mediated angioedema and the medications that target their peptidases. When the drugs in orange circles inhibit these peptidases, they prevent the breakdown of BK, allowing BK to accumulate and stimulate its receptor B2, leading to vasodilation, increased vascular permeability, and angioedema. The drugs in blue rectangles are inhibitors of BK accumulation and can be used for the treatment of BK-mediated angioedema.
Original figure modified for this publication. From: Hudey SN, Westermann-Clark E, Lockey RF. Cardiovascular and Diabetic Medications That Cause Bradykinin-Mediated Angioedema. J Allergy Clin Immunol Pract 2017; 5:610. Illustration used with the permission of Elsevier Inc. All rights reserved.
