| IgG4-RD | Sjögren's syndrome |
Gender distribution | 2.5:1 male:female ratio | 9:1 female:male ratio |
Clinical presentation | Mild or no salivary gland dysfunction | Significant salivary gland dysfunction (xerostomia) |
Persistent salivary gland swelling | Intermittent salivary gland swelling |
Circulating antibodies | Serum IgG4 and IgE levels typically elevated | Serum IgG4 and IgE levels usually normal |
Anti-Ro/SSA and anti-LA/SSB rarely present | Anti-Ro/SSA (with or without anti-LA/SSB) commonly present |
ANA detectable in 25% of patients | ANA detectable in 90% of patients |
Rheumatoid factor detected in 25% of patients | Rheumatoid factor detected in 60% of patients |
Imaging | No abnormality of salivary glands seen on sialography | Punctate and globular sialectasis seen on sialography |