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Serial MRI in opioid-associated amnestic syndrome

Gadolinium-enhanced MRI on day 7 shows bilateral gyriform hippocampal apparent diffusion coefficient hypointensity (A) with corresponding hyperintensity on diffusion-weighted imaging (B), indicating restricted hippocampal diffusivity (arrows). Hippocampal T₂ hyperintensity (C; dashed arrows) along with subtle hippocampal gadolinium enhancement (D; thick arrows) is also seen. Follow-up MRI on day 12 shows resolution of hippocampal restricted diffusion (E) and resolution of T₂ hyperintensity (F).

MRI: magnetic resonance imaging.

From: Taylor RG, Budhram A, Lee DH, Mirsattari SM. Opioid-associated amnestic syndrome observed with fentanyl patch use. Can Med Assoc J 2019; 191:E337. Copyright © 2019 Canadian Medical Association. Copied under license from Access Copyright. Further reproduction, distribution or transmission is prohibited except as otherwise permitted by law.

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