| Medication | Gestational age (GA) or weight | Dosing |
| Antibiotics | ||
| Benzylpenicillin[1] | 36 to <38 weeks | 75,000 units/kg per day, given every 8 hours. |
| 38 to <42 weeks | 150,000 units/kg per day, given every 8 hours. | |
| >42 weeks | 200,000 units/kg per day, given every 8 hours. | |
| Amoxicillin[2] | 36 to <38 weeks | 50 mg/kg per day, given every 8 hours. |
| >38 weeks | 75 mg/kg per day, given every 8 hours. | |
| Gentamicin[3,4] | 36 to <42 weeks | 5 mg/kg given every 36 hours. |
| >42 weeks | 5 mg/kg given every 24 hours. | |
| Morphine[5,6] | 36 weeks and greater | Loading dose 50 mcg/kg followed by continuous infusion of 5 mcg/kg per hour. |
| Antiseizure medications | ||
| Phenobarbital[5] | 36 weeks and greater | Loading dose 30 mg/kg, additional dose of 10 mg/kg if seizures persist. |
| Midazolam[6] | 36 weeks and greater | Loading dose 0.1 mg/kg followed by continuous infusion of 0.15 mg/kg per hour. |
| Lidocaine[7] | Weight 2 to <2.5 kg | Initial loading dose of 2 mg/kg administered over 10 minutes, followed by infusion rate of 6 mg/kg per hour over 3.5 hours. Maintenance dosing starts at 3 mg/kg for first 12 hours and is decreased to 1.5 mg/kg per hour. |
| Weight 2.5 and greater | Initial loading dose of 2 mg/kg administered over 10 minutes, followed by infusion rate of 6 mg/kg per hour over 3.5 hours. Maintenance dosing starts at 3 mg/kg for first 12 hours and is decreased to 1.5 mg/kg per hour. | |
| Levetiracetam[8,9] | 36 weeks and greater and weight greater than 2.5 kg | Loading dose 20 mg/kg, to be repeated if needed. Maintenance dose 10 to 20 mg/kg, given every 12 hours. |
