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Calculator: Mutation and Karyotype-Enhanced International Prognostic Scoring System for Primary Myelofibrosis in adults 70 and younger (MIPSS70+ version 2.0)


Calculator: Mutation and Karyotype-Enhanced International Prognostic Scoring System for Primary Myelofibrosis in adults 70 and younger (MIPSS70+ version 2.0)

 
Karyotype

VHR karyotype (4 points)

Unfavorable karyotype (3 points)

Other karyptype (0 points)
HMR mutations

≥2 HMR mutations (3 points)

1 HMR mutation (2 points)

No HMR mutations (0 points)
Absence of type 1/like CALR mutation

Yes (2 points)

No (0 points)
Presence of constitutional symptoms

Yes (2 points)

No (0 points)
Anemia severity

Severe anemia (2 points)

Moderate anemia (1 point)

Mild or no anemia (0 points)
≥2% circulating blasts

Yes (1 point)

No (0 points)

 
Important: Inputs must be complete to perform calculation.

 
Total criteria point count:
 

 

Interpretation

 
MIPSS70+ version 2.0 score (points) Risk group 10-year overall survival Median overall survival (years)
0 Very low risk 86% Not reached
1 to 2 Low risk 50% 10.3
3 to 4 Intermediate risk 30% 7
5 to 8 High risk 10% 3.5
9 to 14 Very high risk <3% 1.8

 
Notes
  • Cytogenetics:
    • Very high risk (VHR): Single/multiple abnormalities of -7, i(17q), inv(3)/3q21, 12p-/12p11.2, 11q-/11q23, or other autosomal trisomies not including + 8/ + 9 (eg, +21, +19).
    • Favorable: Normal karyotype or sole abnormalities of 13q-, +9, 20q-, chromosome 1 translocation/duplication or sex chromosome abnormality including -Y.
    • Unfavorable: All other abnormalities.
  • High molecular risk (HMR) mutations: ASXL1, SRSF2, EZH2, IDH1, IDH2, U2AF1 Q157.
  • Anemia:
    • Severe: Hemoglobin (Hgb) <8 g/dL [<80 g/L] in women and <9 g/dL [<90 g/L] in men.
    • Moderate: Hgb 8 to 9.9 g/dL [80 to 99 g/L]in women and 9 to 10.9 g/dL [90 to 109 g/L] in men.

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

Legal Notices and Disclaimer

All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

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