Your activity: 88 p.v.
< Back
your limit has been reached. plz Donate us to allow your ip full access, Email: sshnevis@outlook.com

Prevalence of high levels of microsatellite instability (MSI-H) in tumor/normal paired samples across 39 human cancer types

Prevalence of high levels of microsatellite instability (MSI-H) in tumor/normal paired samples across 39 human cancer types
(A) Microsatellite instability prevalence was detected across 39 tumor types.
(B) The relative level of instability, as measured by MANTIS score, is shown across all 39 tumor types. Note that for CLL, the listed microsatellite instability prevalence in panel A is out of 279 patients, and all 338 tumors are shown in panel B. The MANTIS threshold cutoff of 0.4 is depicted with a dashed line.
UCEC: uterine corpus endometrial carcinoma; COAD: colon adenocarcinoma; STAD: stomach adenocarcinoma; READ: rectal adenocarcinoma; ACC: adrenocortical carcinoma; UCS: uterine carcinosarcoma; CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma; WT: Wilms tumor; MESO: mesothelioma; ESCA: esophageal carcinoma; BRCA: breast carcinoma; KIRC: kidney renal clear cell carcinoma; OV: ovarian serous cystadenocarcinoma; CHOL: cholangiocarcinoma; THYM: thymoma; LIHC: liver hepatocellular carcinoma; HNSC: head and neck squamous cell carcinoma; SARC: sarcoma; SKCM: skin cutaneous melanoma; LUSC: lung squamous cell carcinoma; PRAD: prostate adenocarcinoma; LUAD: lung adenocarcinoma; BLCA: bladder carcinoma; NBL: pediatric neuroblastoma; LGG: lower grade glioma; CLL: chronic lymphocytic leukemia; GBM: glioblastoma multiforme; AML: pediatric acute myeloid leukemia; CTCL: cutaneous T-cell lymphoma; DLBC: diffuse large B-cell lymphoma; KICH: kidney chromophobe; KIRP: kidney renal papillary cell carcinoma; LAML: acute myeloid leukemia; NPC: nasopharyngeal carcinoma; PAAD: pancreatic adenocarcinoma; PCPG: pheochromocytoma and paraganglioma; TGCT: testicular germ cell tumor; THCA: thyroid carcinoma; UVM: uveal melanoma; MANTIS: Microsatellite Analysis for Normal-Tumor InStability.
From: Bonneville R, Krook MA, Kautto EA, et al. Landscape of Microsatellite Instability Across 39 Cancer Types. JCO Precis Oncol 2017. Reprinted with permission. Copyright © 2017 American Society of Clinical Oncology. All rights reserved.
Graphic 120779 Version 2.0