Your activity: 239 p.v.
your limit has been reached. plz Donate us to allow your ip full access, Email:

Calculator: Khorana score for estimating venous thromboembolism risk in adults with cancer

Calculator: Khorana score for estimating venous thromboembolism risk in adults with cancer

Site of primary tumor

Very high risk (stomach, pancreas) (2 points)

High risk (lung, lymphoma, gynecologic, bladder, testicular) (1 point)

All other sites (0 points)
Laboratory results and BMI

Prechemotherapy platelet count ≥350,000/microL [≥350 X 109/L] (1 point)

Hemoglobin level <10 g/dL [<100 g/L] or use of ESAs (1 point)

Prechemotherapy WBC >11,000/microL [≥11 X 109/L] (1 point)

BMI ≥35 kg/m2 (1 point)

Important: Inputs must be complete to perform calculation.

Total criteria point count:


Incidence of VTE based on Khorana score

Khorana score points Risk Derivation cohort[1] VTE risk after 2.5 months Validation cohort[1] VTE risk after 2.5 months Independent cohort[2] VTE risk after 6 months Patients in phase I trials[3] VTE risk after 2 months
0 Low 0.8% 0.3% 1.5% 1.5%
1 to 2 Intermediate 1.8% 2% 3.8% (1 point); 9.6% (2 points) 4.8%
3 to 6 High 7.1% 6.7% 17.7% 12.9%

  • The Khorana score was developed from a cohort of 2701 patients with cancer receiving a first course of chemotherapy to predict the cumulative incidence of VTE at 2.5 months.[1] The score was validated in a cohort of 1365 patients, most of whom (91%) had an ECOG performance status of 0 or 1.[1]
  • The score was tested independently in 819 patients with newly diagnosed cancer or cancer progression who had not received chemotherapy within the preceding 3 months to predict the cumulative incidence of VTE at 6 months,[2] and in 1415 patients enrolled in phase I clinical trials followed for a median of 2 months.[3]
  • BMI: body mass index; ESAs: erythropoiesis-stimulating agents; WBC: white blood count; BMI: body mass index; VTE: venous thromboembolism; ECOG: Eastern Cooperative Oncology Group.

Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

Legal Notices and Disclaimer

All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

EBMcalc is Copyright © 1998-2023 Foundation Internet Services, LLC

Topic 120626 Version 5.0