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Uptodate Reference Title
Cause of loud S1 with mitral stenosis
Cause of loud S1 with mitral stenosis
This schematic representation shows the transition between left atrial (LA) and left ventricular (LV) pressures at end-diastole in the normal heart (A) and in a patient with mitral stenosis (B). In B, a significant pressure gradient remains at end-diastole. Note that at low LA pressures, the rate of LV pressure development (dP/dt) is much slower than when crossover occurs at higher LA pressures. Hence, the rate of mitral valve closure is increased in mitral stenosis, the principal cause of a loud S1.