| | Angiolymphoid hyperplasia with eosinophilia | Kimura disease |
| Age of onset | - All ages, peak incidence second to fourth decade
| |
| Clinical features |
| Sex | | |
| Ethnicity | | |
| Body location | - Head and neck most common
| |
| Clinical appearance | - Cutaneous papules and nodules
| |
| Regional lymphadenopathy | | |
| Systemic involvement | | - Associated with renal disease in approximately 20% of cases
|
| Clinical course | | |
| Laboratory tests |
| Peripheral eosinophilia | | |
| Serum IgE levels | | |
| Histopathology |
| Depth | | |
| Main findings | - Proliferation of blood vessels of varying sizes lined by plump endothelial cells
- Mild fibrous stromal reaction
| - Florid lymphoid follicles with germinal center formation
- Hyperplastic small blood vessels lined by flat or cuboidal endothelial cells
- Prominent stromal fibrosis
|
| Infiltrate | - Mixed, lymphocytes and variable number of eosinophils
| - Dense inflammatory infiltrate of lymphocytes, plasma cells, histiocytes, eosinophils
- Eosinophilic microabscesses
|
| Lymph nodes | | - Preserved nodal architecture, follicular hyperplasia with reactive germinal centers, IgE deposition in the germinal centers
|
