Your activity: 62 p.v.
your limit has been reached. plz Donate us to allow your ip full access, Email: sshnevis@outlook.com

Endocrine-disrupting chemicals

Endocrine-disrupting chemicals
EDC Route of exposure[1] Activity Outcome in humans Prevention
BPA
  • Contaminated food, water
  • Prenatal exposure
  • Anti-androgenic[2]
  • Decreased sperm quality
  • Sperm DNA damage[3]
  • Use of BPA-free household products
DDT
  • Imported food/seafood
  • Water, air, dust
  • Prenatal exposure
  • Estrogenic
  • Possible increased risk of human breast cancer[4]
  • Cook seafood thoroughly
  • Repeated washing of produce
DES
  • Pharmaceutical exposure
  • Prenatal exposure
  • Estrogenic
  • Infertility, reproductive tract abnormalities, cancer[5,6]
  • For males with in utero exposure: regular prostate and testicular cancer screening examinations
  • For females with in utero exposure: gynecological screening for vaginal/cervical clear cell adenocarcinoma[7]
Dioxin
  • Contaminated food, water
  • Inhalation
  • Context-dependent estrogenic, androgen agonist/activity
  • Increase in diabetes, gastrointestinal and lymphatic cancers[8]
  • Stricter control of industrial processes
  • Choose organic produce
  • Avoid use of bleached paper products (diapers, paper towels)
Genistein
  • Food (soy, legumes, grains, nuts)
  • Estrogenic
  • Cancer: pro- or antiproliferative depending on dose and tissue type[9]; protective in breast cancer[10]
  • Avoid concentrated soy proteins[11]
Phthalates
  • Food packaging, cosmetics, household products
  • Prenatal exposure
  • Anti-androgenic[2]
  • Alterations in neonatal androgens and Leydig cell function[12]
  • Use of filtered water
  • Avoiding plastics in food preparation and storage
  • Use of fragrance-free products
PCBs
  • Contaminated food
  • Occupational exposure through inhalation and skin by industrial and construction materials manufactured before 1978 in the United States and 2004 worldwide[13]
  • Context-dependent androgen agonist/activity
  • Weak estrogenic
  • Prostate cancer[14]
  • Dermal lesions[15]
  • Use of protective clothing and facial and respiratory protective equipment when working with industrial or construction materials manufactured before 1978
EDC: endocrine-disrupting chemical; BPA: bisphenol A; DDT: dichlorodiphenyltrichloroethane; DES: diethylstilbestrol; PCBs: polychlorinated biphenyls.
References:
  1. Gore AC, Crews D, Doan LL, et al. Introduction to Endocrine Disrupting Chemicals (EDCs): A Guide for Public Interest Organizations and Policy-Makers. Endocrine Society: Washington, DC, USA, 2014.
  2. De Falco M, Forte M, Laforgia V. Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system. Front Environ Sci 2015; 3.
  3. Meeker JD, Ehrlich S, Toth TL, et al. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. Reprod Toxicol 2010; 30:532.
  4. Snedeker SM. Pesticides and breast cancer risk: A review of DDT, DDE, and dieldrin. Environ Health Perspect 2001; 109:35.
  5. Conlon JL. Diethylstilbestrol: Potential health risks for women exposed in utero and their offspring. JAAPA 2017; 30:49.
  6. Titus-Ernstoff L, Troisi R, Hatch EE, et al. Birth defects in the sons and daughters of women who were exposed in utero to diethylstilbestrol (DES). Int J Androl 2010; 33:377.
  7. Schrager S, Potter BE. Diethylstilbestrol exposure. Am Fam Physician 2004; 69:2395.
  8. Bertazzi PA, Bernucci I, Bramvilla G, et al. The Seveso studies on early and long-term effects of dioxin exposure: A review. Environ Health Perspect 1998; 106:625.
  9. Russo M, Russo GL, Daglia M, et al. Understanding genistein in cancer: The "good" and the "bad" effects: A review. Food Chem 2016; 196:589.
  10. Shu XO, Zheng Y, Cai H, et al. Soy food intake and breast cancer survival. JAMA 2009; 302:2437.
  11. Soy and Your Health. Physicians Committee for Responsible Medicine. Available at: https://www.pcrm.org/health/health-topics/soy-and-your-health (Accessed on October 3, 2018).
  12. Main KM, Mortensen GK, Kaleva MM, et al. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect 2006; 114:270.
  13. Porta M, Zumeta E. Implementing the Stockholm Treaty on Persistent Organic Pollutants. Occup Environ Med 2002; 59:651.
  14. Gore AC, Chappell VA, Fenton SE, et al. EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev 2015; 36:E1.
  15. Maroni M, Colombi A, Arbosti G, et al. Occupational exposure to polychlorinated biphenyls in electrical workers. II. Health effects. Br J Ind Med 1981; 38:55.
Graphic 119309 Version 2.0