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Risks and benefits of contraceptive options in women with CKD

Risks and benefits of contraceptive options in women with CKD
Contraceptive options Risks Benefits
IUDs
  • Risk of expulsion and perforation
  • Increased risk of ectopic pregnancy should pregnancy occur, which is rare
  • Most effective contraceptive category
  • Long acting and reversible
  • No evidence for increased risk of pelvic inflammatory disease
  • No increased risk of hypertension, vascular disease, or venous thrombosis
Copper IUD
  • Change in menstrual bleeding pattern: heavier
  • Contains no hormones
IUD with progestin
  • Change in menstrual bleeding pattern: lighter to amenorrhea
  • Contains levonorgestrel
  • Lighter periods
Combined estrogen-progestin hormonal methods  
  • Highly effective contraceptive category
Combined estrogen-progestin oral contraceptive pills (COC)
  • Worsening of hypertension, worsening of proteinuria, and increased risk of venous thrombosis, stroke, and myocardial infraction
  • Needs to be taken daily
  • Improved cycle control
Transdermal contraceptive patch (ethinyl estradiol and norelgestromin)
  • Application site reactions
  • Higher overall estrogen dose and risk of venous thrombosis compared with COC
  • Convenient weekly application
  • No increased risk of hypertension or vascular disease, because it does not stimulate the RAAS
Contraceptive vaginal ring (etonogestrel/ethinyl estradiol)
  • Increased risk of venous thrombosis, stroke, and myocardial infraction similar to COC
  • Once a month self-administered use
Progestin-only hormonal methods    
Etonogestrel implant
  • Change in bleeding pattern with unscheduled bleeding
  • Possible increased risk of thrombotic events
  • Most effective contraceptive category
Depot medroxyprogesterone acetate
  • Change in bleeding pattern with unscheduled bleeding
  • Decreased bone density
  • Should not be used in patients with CV risk factors
  • Highly effective contraceptive category
  • Administration every 3 months
Progestin-only preparations
  • Change in bleeding pattern with unscheduled bleeding
  • Higher failure rate if not taken consistently within 3 hours each day
  • Highly effective contraceptive category
  • No increased risk of hypertension, vascular disease, or venous thrombosis
Pericoital methods  
  • Least effective contraceptive method 
  • Contain no hormones
  • Used only when needed
Condoms with or without spermicides
  • Least effective category of contraceptive methods
  • Protection against STIs
Diaphragms
  • No protection against STIs
 
Spermicide and spermicidal sponge
  • No protection against STIs
 
Sterilization procedures (male vasectomy and female tubal ligation)
  • Surgical risk
  • Most effective contraceptive category
  • Permanent
CKD: chronic kidney disease; IUD: intrauterine device; RAAS: renin-angiotensin-aldosterone system; CV: cardiovascular; STI: sexually transmitted disease.
Adapted with permission from: Bramham K, Hladunewich MA, Jim B, Maynard SE. Postpartum care. Nephrol Self Assess Program 2016; 15:141. Copyright © 2016 American Society of Nephrology.
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