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Adverse effects in selected North American trials of medical abortion regimens

Adverse effects in selected North American trials of medical abortion regimens
Trial Incidence of adverse effects (%)
Nausea Vomiting Diarrhea Headache Dizziness Thermoregulatory effects*
Mifepristone Misoprostol Mifepristone Misoprostol Mifepristone Misoprostol Mifepristone Misoprostol Mifepristone Misoprostol Mifepristone Misoprostol
Schaff (1997) 36 36 14 14 8 22 18 19 22 37 20 37
Schaff (1999)Δ 45 43 13 26 11 23 14 13 15 28 14 32
Wiebe (2002)◊ 45 39 13 15 5 16 19 29 N/R N/R N/R 23
Creinin (2004)§ 20 44 5 23 1 27 10 37 12 35 9 56
39 52 14 30 7 25 20 37 20 37 19 53
Creinin (2007)¥ N/R 58 N/R 31 N/R 35 N/R 40 N/R 39 N/R 69
29 51 9 31 5 26 18 36 9 37 15 56
Winikoff (2008)‡ N/R 64 N/R 40 N/R 35 N/R 31 N/R 30 N/R 33
N/R 66 N/R 40 N/R 34 N/R 34 N/R 32 N/R 41
N/R: not reported.
* Fever, warmth, hot flushes, or chills.
¶ Mifepristone, 600 mg, followed by misoprostol, 800 mcg vaginally, 36 to 48 hours later.[1]
Δ Mifepristone, 200 mg, followed by misoprostol, 800 mcg vaginally, 48 hours later.[2]
◊ Mifepristone, 600 mg, followed by misoprostol, 400 mcg orally, 36 to 48 hours later.[3]
§ Mifepristone, 200 mg, followed by misoprostol, 800 mcg vaginally, 6 to 8 hours later (first row) or 24 hours later (second row).[4]
¥ Mifepristone, 200 mg, followed by misoprostol, 800 mcg vaginally, 0 to 15 minutes later (first row) or 24 hours later (second row).[5]
‡ Mifepristone, 200 mg, followed by misoprostol, 800 mcg orally (first row) or buccally (second row), 24 to 36 hours later.[6]
References:
  1. Schaff EA, Stadalius LS, Eisinger SH, Franks P. Vaginal misoprostol administered at home after mifepristone (RU486) for abortion. J Fam Pract 1997; 44:353.
  2. Schaff EA, Eisinger SH, Stadalius LS, et al. Low-dose mifepristone 200 mg and vaginal misoprostol for abortion. Contraception 1999; 59:1.
  3. Wiebe E, Dunn S, Guilbert E, et al. Comparison of abortions induced by methotrexate or mifepristone followed by misoprostol. Obstet Gynecol 2002; 99:813.
  4. Creinin MD, Fox MC, Teal S, et al. A randomized comparison of misoprostol 6 to 8 hours versus 24 hours after mifepristone for abortion. Obstet Gynecol 2004; 103:85.
  5. Creinin MD, Schreiber CA, Bednarek P, et al. Mifepristone and misoprostol administered simultaneously compared with 24 hours apart for abortion: a randomized controlled trial. Obstet Gynecol 2007; 109:885.
  6. Winikoff B, Dzuba IG, Creinin MD, et al. Two distinct oral routes of misoprostol in mifepristone medical abortion. A randomized controlled trial. Obstet Gynecol 2008; 112:1303.
Reproduced from: Medical management of first-trimester abortion. Contraception 2014; 89:148. Table used with the permission of Elsevier Inc. All rights reserved.
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