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Vaccinations for adults (age >19 years) with impaired splenic function and adults undergoing splenectomy in the United States*

Vaccinations for adults (age >19 years) with impaired splenic function and adults undergoing splenectomy in the United States*
Vaccine Primary series Revaccination (booster)
Pneumococcal vaccine
  • PCV20 alone or PCV15 plus PPSV23
 1 dose of PCV20 or PCV15. If PCV15 is used, 1 dose of PPSV23 ≥8 weeks later Not applicable
Haemophilus influenzae type b vaccine
  • Hib
 1 dose Not applicable
Meningococcal serotype ACWY vaccine
  • MenACWY (Menactra, Menveo, or MenQuadfi)
 2 doses at least 8 weeks apartΔ Every 5 years
Meningococcal serotype B
  • MenB-FHbp (Trumenba) or MenB-4C (Bexsero)
 2 doses of MenB-4C at least 1 month apart or 3 doses of MenB-FHbp at 0, 1 to 2, and 6 months◊ 1 year after completing the primary series and every 2 to 3 years thereafter
Seasonal influenza virus 1 dose annually at the start of influenza season Repeat annually at start of influenza season
This table should be used in conjunction with the UpToDate topic on prevention of sepsis in patients with impaired splenic function. In addition to the vaccines above, patients with impaired splenic function should also receive all routinely recommended age-appropriate vaccines (including coronavirus disease 2019 [COVID-19] vaccination). For patients undergoing elective splenectomy, vaccinations should be given at least 14 days prior to the procedure and ideally 10 to 12 weeks prior. For patients undergoing emergency splenectomy, vaccine series should be started 14 days after splenectomy. For patients with nonsurgical asplenia or hyposplenism, vaccinations should be given as soon as impaired splenic function is recognized.

PCV20: 20-valent pneumococcal conjugate vaccine; PCV15: 15-valent pneumococcal conjugate vaccine; 23-valent pneumococcal polysaccharides: PPSV23.

* Available vaccine formulations and recommendations may differ outside of the United States.

¶ Hib vaccination is recommended for all adults who have not been previously vaccinated or if vaccination status is unknown.

Δ If primary series already received, continue revaccinating every 5 years.

◊ If not already received.
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