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Mechanisms of nephrogenic diabetes insipidus due to hypercalcemia, hypokalemia, and lithium toxicity
Mechanisms of nephrogenic diabetes insipidus due to hypercalcemia, hypokalemia, and lithium toxicity
AQP2: aquaporin 2; CaSR: calcium sensing receptor; Ca
2+
: calcium ion; ENaC: epithelial sodium channel; Li
+
: lithium ion; K
+
: potassium ion; K-3: gycogen synthase kinase-3; P: phosphate; Red oval with black line: inhibits; UT-A1: urea transporter A1.
Adapted from: Khositseth S, Charngkaew K, Boonkrai C, et al. Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus. Kidney Int 2017; 91:1070.
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