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General strategies to reduce the risk of spinal epidural hematoma (SEH) in individuals receiving anticoagulant or antiplatelet medications

General strategies to reduce the risk of spinal epidural hematoma (SEH) in individuals receiving anticoagulant or antiplatelet medications
Before catheter placement or removal
  • Ensure an appropriate interval after last dose of anticoagulant or antiplatelet agent
  • Document normal coagulation testing where appropriate (eg, after discontinuing therapeutic dose heparin or warfarin)
  • Verify no other coagulation or platelet disorders*
During catheter placement
  • Use the smallest needle possible needle (consider spinal rather than epidural technique)
  • If appropriate, use a single injection rather than a continuous catheter
After catheter placement
  • Ensure an appropriate interval between catheter placement or removal and the first dose of anticoagulant medication (only applies to medications considered safe during catheter maintenance)
  • Ensure an appropriate interval between the last dose of anticoagulant medication and catheter removal
  • Perform frequent neurologic checks
  • Use smallest effective concentration of local anesthetic to allow for early recognition of sensory or motor changes
  • Obtain emergency imaging if SEH is suspected
After neuraxial procedure or neuraxial catheter removal
  • Ensure an appropriate interval between the neuraxial procedure or catheter removal and the first dose of an anticoagulant/antiplatelet agent
  • Use a longer interval between traumatic neuraxial procedure and the first dose of an anticoagulant/antiplatelet agent
  • Perform frequent neurologic checks
  • Obtain emergency imaging if SEH is suspected
If SEH is detected
  • Use the emergency reversal agent(s) appropriate for any anticoagulant medication
  • Give emergency platelet transfusion if an antiplatelet medication is in effect
  • Obtain emergency neurosurgical consultation for possible decompressive surgery
Refer to the UpToDate table on the timing of neuraxial anesthesia during antithrombotic therapy. Refer to UpToDate topics on neuraxial anesthesia for additional information on the risks of SEH and strategies to reduce these risks.
SEH: spinal epidural hematoma; MRI: magnetic resonance imaging; CT: computed tomography
* A thorough bleeding history is often sufficient, but laboratory testing may be appropriate in selected patients.
¶ MRI is preferred; CT can be used if MRI is contraindicated or unavailable.
Graphic 118905 Version 1.0