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Risk factors for tardive dyskinesia

Risk factors for tardive dyskinesia
Patient characteristics
  • Older age
  • Female sex
Drug exposure characteristics*
  • First > second-generation antipsychotics
  • Cumulative duration
  • Higher dose
  • Early occurrence of drug-induced movement disorders
Comorbidities
  • Schizophrenia and other psychotic disorders
  • Intellectual disability
  • Preexisting mood disorder
  • Alcohol or substance use disorder
  • Dementia
  • Diabetes
Others
  • Prior electroconvulsive therapy
* All dopamine receptor-blocking agents have the potential to cause tardive dyskinesia. The most commonly implicated drugs are first-generation antipsychotic drugs, second-generation antipsychotic drugs, and metoclopramide.
¶ Not as great a difference as once thought.
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