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Uptodate Reference Title
Major congenital malformation rates with ASMs in NAAPR and EURAP and other registries
Major congenital malformation rates with ASMs in NAAPR and EURAP and other registries
Comparative safety of antiseizure medication monotherapy during pregnancy. Overall rates (%) of major congenital malformations for different antiseizure medication monotherapies as revealed by different registries: NAAPR[1] and EURAP[2]. The total sample size (n) included in each treatment is also presented; studies of <50 patients were not included.
ASM: antiseizure medication; NAAPR: North American Antiepileptic Drug Pregnancy Registry; EURAP: International Registry of Antiepileptic Drugs and Pregnancy; MCM: major congenital malformation.
Data from:
Hernández-Díaz S, Smith CR, Shen A, et al. Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012; 78:1692.
Tomson T, Battino D, Bonizzoni E, et al. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol 2018; 17:530.
