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Major causes of bilateral lower extremity edema
Major causes of bilateral lower extremity edema
Acute edema
Medications
Heart failure
Nephrotic syndrome
Venous thrombosis
Acute worsening of chronic causes
Chronic edema
Venous insufficiency
Heart failure
Left-sided with preserved or reduced ejection fraction
Right-sided
Pulmonary hypertension (including sleep apnea)
Restrictive pericarditis
Restrictive cardiomyopathy
Renal disease (including nephrotic syndrome)
Liver disease (early cirrhosis)
Premenstrual edema
Pregnancy
Malnutrition (including malabsorption and protein losing enteropathy)
Pelvic compression (including tumor or lymphoma)
Dependent edema
Sodium or fluid overload (including parenteral fluids, antibiotics and other drugs with large amounts of sodium)
Refeeding edema
Idiopathic edema
Inflammation (including sepsis)
Medications
Chronic lymphedema
Primary lymphedema (presenting in childhood)
Secondary lymphedema (including lymph node dissection)
Thyroid disease (myxedema)
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