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Recommended parenteral intakes of different nutrients in early parenteral nutrition for premature infants (initial amount), and for "full" parenteral nutrition (target amount)

Recommended parenteral intakes of different nutrients in early parenteral nutrition for premature infants (initial amount), and for "full" parenteral nutrition (target amount)
Component Initial amount Target amount
Energy 30 to 40 kcal/kg/day[1] 85 to 95 kcal/kg/day[1]
Amino acid

1.5 to 3.0 g/kg/day[1]

OR

2 g/kg/day[2]

4.0 g/kg/day[1]

OR

Weight-based dosing:[2]
  • Weight <1500 g: 4 g/kg/day
  • Weight >1500 g: 3 g/kg/day
Lipid 0 to 1 g/kg/day 2 to 3 g/kg/day[1]
Calcium

25 to 40 mg/kg/day[1]

OR

30 to 50 mg/kg/day[2]		 65 to 100 mg/kg/day[1]
Phosphorus None 50 to 80 mg/kg/day
Sodium

None

OR

2 to 4 mEq/kg/day[2]

69 to 115 mg/kg/day

OR

3 to 5 mEq/kg/day[3]
Potassium

None

OR

2 to 4 mEq/kg/day[2]

78 to 117 mg/kg/day[3]

OR

2 to 3 mEq/kg/day[3]
Magnesium 0 to 3 mg/kg/day[1]

7 to 10 mg/kg/day[1]

OR

4.3 to 7.2 mg/kg/day[2]
Iron None 0.0 to 0.25 mg/kg/day[1]
Zinc None 0.4 mg/kg/day[1]
Copper None

40 mcg/kg/day[1]

OR

20 mcg/kg/day[4]
Selenium None 1.5 to 4.5 mcg/kg/day[3]
Manganese None 1 mcg/kg/day[1]
Chromium None 0.05 to 0.3 mcg/kg/day[1]
Carnitine None

10 mg/kg/day[2]

OR

2.9 mg/kg/day[4]
Vitamin A None 700 to 1500 IU/kg/day[3]
Vitamin C None 15 to 25 mg/kg/day[4]
Vitamin D None 40 to 160 IU/kg/day[3]
Vitamin E None 2.8 to 3.5 IU/kg/day[3]
Vitamin K None 10 mcg/kg/day[3]
Vitamin B1 (thiamine) None 200 to 350 mcg/kg/day[3]
Vitamin B2 (riboflavin) None 150 to 200 mcg/kg/day[3]
Vitamin B3 (niacin) None 4.0 to 6.8 mg/kg/day[3]
Vitamin B5 (pantothenate) None 1 to 2 mg/kg/day[4]
Vitamin B6 (pyridoxine) None 150 to 200 mcg/kg/day[3]
Vitamin B7 (biotin) None 5 to 8 mcg/kg/day[4]
Vitamin B9 (folic acid) None 56 mcg/kg/day[3]
Vitamin B12 (cobalamin) None 0.3 mcg/kg/day[3]
Typical target ranges for parenteral nutrition for premature infants in stable clinical condition, as recommended by several sources. For some nutrients, the target range differs among sources. In this case, all data is provided, for comparison.
IU: international units.
References:
  1. Nutritional care of preterm infants: Scientific basis and practical guidelines, Koletzko B, Poindexter B, Uaay R (Eds), Karger, Basel (Switzerland) 2014.
  2. Tellier B, Silverman S. Prematurity in: Manual of Pediatric nutrition 5th ed, Sonneville K, Duggan C (Eds), People's Medical Publishing House-USA, Shelton, CT, 2014.
  3. Schanler RJ, Anderson D. The low birth-weight infant: Inpatient care. In: Nutrition in pediatrics, 4th ed, Duggan C, Watkins JB, Walker WA (Eds), BC Decker Inc, Hamilton (Ontario, Canada) 2008.
  4. AAP Committee on Nutrition. Pediatric Nutrition, 7th Edition, Kleinman RE, Greer FR (Eds) American Academy of Pediatrics, Elk Grove (IL); 2014.
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