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Constellation of findings that should prompt consideration of botulism

Constellation of findings that should prompt consideration of botulism
At least one of the following symptoms of cranial neuropathy:
Blurred vision
Double vision
Difficulty speaking, including slurred speech
Any change in sound of voice, including hoarseness
Dysphagia/pooling of secretions/drooling
Thick tongue sensation
PLUS at least one of the following signs of neuropathy:
Ptosis
Signs suggestive of extraocular neuropathy
    • Extraocular palsy
    • Decreased tracking of objects
    • Fatigability manifested by avoiding light shining in the eye
Signs suggestive of facial neuropathy
    • Facial paresis
    • Loss of facial expression
    • Poor feeding or poor suck using pacifier
    • Fatigability while eating
Fixed pupils (not including abnormally or sluggishly reactive pupils)
Descending paralysis, beginning with cranial nerves
PLUS lack of fever (temperature ≤37.8°C or ≤100.4°F)
These clinical criteria have been proposed as a tool to improve identification of patients with botulism. When all three are present, the sensitivity for botulism is approximately 78 to 89%. The specificity is unknown.
Adapted from: Rao AK, Lin NH, Griese SE, et al. Clinical Criteria to Trigger Suspicion for Botulism: An Evidence-Based Tool to Facilitate Timely Recognition of Suspected Cases During Sporadic Events and Outbreaks. Clin Infect Dis 2018; 66:S38.
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