Finding | Implications |
Findings associated with conditions that could lead to NAFLD |
Overweight (BMI ≥85th percentile) or obese (BMI >95th percentile) | |
Goiter | Suggests hypothyroidism |
Abnormal fat distribution | Suggests partial lipodystrophy |
Papilledema, neurologic deficits, short stature, and/or severe obesity | Panhypopituitarism, eg, related to craniopharyngioma or its treatment |
Xanthelasmata | Suggests lysosomal acid lipase deficiency |
Findings associated with risk of advanced NAFLD |
Increased waist circumference | Abdominal obesity |
Acanthosis nigricans | Insulin resistance, diabetes |
Splenomegaly | Portal hypertension |
Sarcopenia (muscle wasting) | Possible advanced liver disease |