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Differential diagnosis in a child with suspected nonalcoholic fatty liver disease[1]

Differential diagnosis in a child with suspected nonalcoholic fatty liver disease[1]
Genetic/metabolic
Lysosomal acid lipase deficiency
Wilson disease
Fatty acid oxidation defects and other mitochondrial disorders
Partial/total lipodystrophy
Abetalipoproteinemia or hypobetalipoproteinemia
Immune-mediated
Celiac disease
Autoimmune hepatitis
Endocrine
Panhypopituitarism
Hypothyroidism
Uncontrolled diabetes
Infectious
Hepatitis C (genotype 3)
HIV-related lipodystrophy
Iatrogenic
Certain psychotropic medications
Corticosteroids
Other medications – Methotrexate, amiodarone
Rapid surgical weight loss
Parenteral nutrition
Reference:
  1. ​Vos MB, Abrams SH, Barlow SE, et al. NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). J Pediatr Gastroenterol Nutr 2017; 64:319.
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