Stakeholder | Date(s) issued | Ovarian cancer recommendations | Uterine cancer recommendations |
Society of Gynecologic Oncology (SGO) | 2014 | Genetic counseling and testing for all ovarian, fallopian tube, peritoneal cancers[1] | Joint ACOG/SGO recommendations: Tumor testing for MSI/MMR IHC on any endometrial or colorectal tumor from a woman at risk for Lynch syndrome by focused personal and family medical history, or all endometrial cancers age <60. Germline testing for marker expression loss on tumor tissue.[4] - Endometrial cancer age <50
- Endometrial cancer dx at age ≥50 if there is a FDR with colorectal or endometrial cancer at any age
- Synchronous or metachronous colorectal or endometrial cancer in the same person
- Endometrial cancer showing mismatch repair deficiency on tumor screening
- Endometrial cancer and 2 additional cases of any LS-associated cancer in the same person or in close relatives
- Epithelial endometrial cancer and 2 additional Cowden syndrome criteria in the same person[3]
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American College of Obstetricians and Gynecologists (ACOG) | 2009 | Patients with greater than an approximate 20 to 25% chance of having a mutation[2] |
National Society of Genetic Counselors (NSGC) [Joint with the American College of Medical Genetics and Genomics (ACMG)] | 2014 | Single case of ovarian, fallopian tube, or peritoneal cancer present in the patient or a first-degree relative[3] |