Male WITHOUT a diagnosis of prostate cancer
and any 1 of the following: | Male WITH a diagnosis of prostate cancer
and any 1 of the following: |
- Known mutation in a cancer susceptibility gene within the family
| - Known mutation in a cancer susceptibility gene within the family
|
- Family history suggestive of hereditary breast and ovarian cancer syndrome
- ≥2 breast cancers in a single person (close relative)
- ≥2 family members with breast cancer on the same side of the family, at least 1 diagnosed ≤50 years of age
- Close relative with ovarian cancer
- Close relative with male breast cancer
- Family history of ≥3 of the following, especially if diagnosed ≤50 years and/or with multiple primary cancers: breast cancer, ovarian cancer, pancreas cancer, prostate cancer (Gleason ≥7 and/or WHO Grade Group ≥2), melanoma, colon cancer, etc
| - Family history suggestive of hereditary breast and ovarian cancer syndrome
- FDR or personal history of male breast cancer
- Family history of ≥2 close relatives with either breast or prostate cancer (any grade) at any age
- FDR and second-degree relatives with exocrine pancreas cancer and prostate cancer (metastatic, intraductal/cribriform, or NCCN guidelines for prostate cancer – high- or very high-risk group)
- Consider for those with Ashkenazi Jewish ancestry
- FDR diagnosed with ovarian cancer (including fallopian tube cancer or peritoneal cancer), exocrine pancreatic cancer
- Probability >5 % of a BRCA1/2 pathogenic variant based on prior probability models (eg, Tyrer-Cuzick, BRCAPro, CanRisk)
|
- Family history suggestive of Lynch syndrome
- ≥1 FDR with colorectal or endometrial cancer diagnosed <50 years
- ≥1 FDR with colorectal or endometrial cancer and another synchronous or metachronous Lynch-syndrome-related cancer, or ≥2 family members with any of the following: colorectal, endometrial, gastric, ovarian, pancreas, ureter and renal pelvis, brain (usually glioblastoma), small intestinal, sebaceous carcinomas and keratoacanthomas
| - Family history suggestive of Lynch syndrome
- ≥1 FDR (especially if diagnosed <50 years) with colorectal, endometrial, gastric, ovarian, pancreas, urothelial, brain (usually glioblastoma), biliary tract, and small intestinal cancers, as well as sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas as seen in Muir-Torre syndrome. With any of the following: colorectal, endometrial, gastric, ovarian, pancreases, ureter and renal pelvis, brain (usually glioblastoma), small intestinal, sebaceous carcinomas and keratoacanthomas
|
- Family history suggestive of hereditary prostate cancer syndrome
- ≥2 prostate cancers on the same side of the family
- FDR who died as a result of prostate cancer <60 years of age
- FDR diagnosed with prostate cancer ≤55 years of age
| - Family history suggestive of hereditary prostate cancer syndrome
- ≥2 prostate cancers on the same side of the family
- FDR who died as a result of PCa <60 years
- FDR diagnosed with PCa ≤55 years
- Personal history of PCa diagnosed ≤55 years and an FDR with PCa at any age
|
| | - Personal history of tumor (somatic) sequencing indicating presence of mutations in hereditary cancer risk genes (eg, BRCA2, BRCA1, ATM, MSH2, MSH6, MLH1, PMS2)
|
| | - Personal history of PCa or other cancer with MMR deficiency determined by PCR, NGS, or IHC
|
| | - Personal history of metastatic PCa
|
| | - Personal history of high-risk and very high-risk localized PCa, and/or intraductal or cribriform histology
|
